Lack of CodY leads to biofilm formation in S. aureus

The Brinsmade Lab is in Regents Hall, which opened in the Summer of 2012

Cherry blossoms and the Washington Monument as seen from the Tidal Basin

Single cell analysis of S. aureus gene expression during infection

Jefferson Memorial and cherry blossoms as seen from the Tidal Basin

We study how bacterial physiology and pathogenesis are intertwined

CodY blocks virulence gene expression when nutrients are abundant

Fluorescently-labeled cells help reveal the mechanism of clumping in codY mutants

Welcome to the Brinsmade Lab at Georgetown University!

We are located in the Department of Biology. Research in the Brinsmade Laboratory seeks to understand how bacteria control pathogenesis using nutritional and host cues during infection. Currently we are focused on the Gram-positive, opportunistic pathogen Staphylococcus aureus.

Recent Papers

Augagneur Y*, King AN*, Germain-Amiot N, Sassi M, Fitzgerald FW, Sahukhal GS, Elasri MO, Felden B, Brinsmade SR. Analysis of the CodY RNome reveals RsaD as a stress-responsive riboregulator of overflow metabolism in Staphylococcus aureus Mol Microbiol 2020. 113(2), 1-17
Behera RK, Mlynek KD, Linz MS, Brinsmade SR. A fluorescence-based method to study bacterial gene regulation in infected tissues J Vis Exp. 2019. 144(), e59055
Mlynek KD, Bulock LL, Stone CJ, Curran LJ, Sadykov MR, Bayles KW, and Brinsmade SR.. Genetic and biochemical analysis of CodY-mediated cell aggregation in Staphylococcus aureus reveals an interaction between eDNA and polysaccharide in the extracellular matrix J Bacteriol. 2020. 202(8), e00593-19

@SBrinsmade

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Lab Info
Georgetown University
Department of Biology
301A Regents Hall
37th and O Streets, N.W.
Washington, DC 20057-1229

Shaun Brinsmade, PhD
Associate Professor

Office: (202) 687-6549
sb1344@georgetown.edu

Links
Georgetown University
Department of Biology